Thalidomide

Thalidomide was a drug that was prescribed to pregnant women in the recently 1950s and early 1960s to help combat flick disease. It effectively reduced the symptoms of morning sickness in those women, just at a horrible cost. Many of the children born from women who took Thalidomide dudoughnut motherliness were born with give defects and were c each(prenominal)ed Thalidomide babies. In reference to the stereochemistry of Thalidomide, in that respect is barely one chiral carbon, and thus just aboriginal isomers. Thalidomide exists in devil stereoisomers, S-thalidomide, which is a sedative that calms nervousness, and R-thalidomide, which was found to be a teratogen that causes birth defects. The carbon atom from the carbon-nitrogen bond connecting the two main ring structures is chiral, as shown on the attached bonus paper. The R-thalidomide isomer is the one that causes all the problems with birth defects, so one skill think that if the S-thalidomide isomer was dispo sed to patients instead, there wouldnt take away been much(prenominal) a dread(a) problem. That, however, isnt the case. Humans convert the S-thalidomide into R-thalidomide once in the body, so it really doesnt matter which enantiomer is taken, it would exact toxic effects to the babies of the pregnant women anyway.

Although the use of Thalidomide for morning sickness and its libellous effects to the babies has been called one of the biggest medical tragedies of modern clock, there was some good to come from finding the awful results. The Thalidomide calamity led to much stricter testing being ask for drugs and pest icides before they can be licensed. In addi! tion, it has been found to be a viable treatment for many medical conditions including threefold myeloma in people who have been recently found to have this disease. Its also used to treat and prevent scramble symptoms of erythema nodosum leprosum(ENL or leprosy).If you want to get a full essay, browse it on our website: OrderCustomPaper.com

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